Both teams will clash at the Cairo International Stadium in a quarter-final clash at the 2019 Africa Cup of Nations (AFCON).
Speaking ahead of the clash, the former Arsenal man, 42, posted on Twitter, calling on football fans to back the team.
“Nigeria vs South Africa. You know what it is,” Kanu said.
“You know what to do Nigerians. Keep supporting the Super Eagles.
“Pray, support and believe. The Super Eagles are ready. They are going to make Nigerians proud.
“We need everyone to be part of this. Keep supporting our dear team the Super Eagles to victory.”