The London Club will hope to follow suit of other English Clubs in the European competition by finishing what they started at Emirates Stadium last week.
Emery is still only without the five players carrying longer-term injuries.
Aaron Ramsey (hamstring) will not play for the club again before moving to Juventus, while Barcelona loanee Denis Suarez (groin), Danny Welbeck (ankle), Hector Bellerin and Rob Holding (both knee) are also sidelined for the season.
Petr Cech is set to start for the Gunners in what could be the very last appearance of a glittering professional career.
Should Arsenal fail to progress it will likely mark the end of his spell with the club, barring his shock inclusion at Burnley on Sunday.
Can we have all English Europa League Final? That is left to be seen at the end of the day as Chelsea host Eintracht Frankfurt at Stamford Bridge.
Arsenal Teams News
Out: Bellerín (knee), Holding (knee), Ramsey (hamstring), Welbeck (ankle)
Valencia Team News
Out: Cheryshev (knee), Kondogbia (thigh)
Valencia vs Arsenal Possible Line-ups
Valencia XI: Neto; Piccini, Gabriel, Diakhaby, Gayà, Soler, Parejo, Wass, Guedes, Mina, Rodrigo
Arsenal XI: Leno, Mustafi, Papastathopoulos, Koscielny, Maitland-Niles, Guendouzi, Xhaka, Kolasinač; Iwobi, Mkhitaryan, Lacazette