Eden Hazard is likely to start in their reverse fixture against German side Eintracht Frankfurt and this should give extra strength to the Blues.
However, Frankfurt have made it a habit of upsetting the odds in this competition.
They welcome back Ante Rebić, one who thrives on the big stage.
Chelsea Team News
Out: Ampadu (back), Hudson-Odoi (Achilles), Kanté (hamstring), Rüdiger (knee).
Eintracht Frankfurt Team News
Out: Stendera (back), Tawatha (ankle)
Doubtful: Haller (stomach)
Chelsea vs Eintracht Frankfurt Possible Line-ups
Chelsea XI: Arrizabalaga, Azpilicueta, Christensen, David Luiz, Emerson Palmieri, Kovačić, Jorginho, Loftus-Cheek, Pedro, Giroud, Hazard
Frankfurt XI: Trapp, Abraham, Hasebe, Hinteregger; Da Costa, Rode, Fernandes, Kostić, Gaćinović, Jović, Rebić/Haller