It will be an uphill task for the Reds as they hope to qualify for their second successive Champions League final.
Jurgen Klopp’s men were defeated 3-0 at Camp Nou in what the coach described as their best European away performance for two years.
Luis Suarez’s early goal and sumptuous Lionel Messi brace gave the Blaugrana advantage going into the second leg.
The treble-chasing Barcelona fell to a shocking 2-0 defeat to Celta Vigo as Ernesto Valverde rested most of his key stars at Balaidos.
Barcelona wrapped up their 26th LaLiga title and eighth in 11 years with three matches to spare.
Liverpool Team News
Out: Firmino (groin), Keïta (groin), Lallana (muscular), Salah (head)
Barcelona Team News
Out: Dembélé (hamstring), Rafinha (knee)
Liverpool vs Barcelona Possible Line-ups
Barcelona XI: Ter Stegen; Semedo, Piqué, Lenglet, Alba; Roberto, Rakitić, Busquets, Vidal; Suárez, Messi
Liverpool XI: Alisson; Alexander-Arnold, Matip, Van Dijk, Robertson; Milner, Wijnaldum, Fabinho, Henderson; Mané, Origi