The Gunners are on a mission to win the competition in order to return to the UEFA Champions League should they fail to finish in the Premier League top four.
Arsenal Team News
Laurent Koscielny and Granit Xhaka remain injury doubts ahead of the visit of the Serie A giants.
Napoli Team News
Lorenzo Insigne and Faouzi Ghoulam both returned to the Napoli squad at the weekend. Italy international Insigne, who has been missing with a thigh injury, has 13 goals and seven assists this season.
Arsenal vs Napoli Possible Line-ups
Arsenal XI: Leno, Mustafi, Sokratis, Monreal, Maitland-Niles, Ramsey, Guendouzi, Kolasinac, Iwobi, Aubameyang, Lacazette
Napoli XI: Karnezis, Hysaj, Maksimovic, Koulibaly, Ghoulam, Callejon, Allan, Fabian, Insigne, Mertens, Milik