After producing one of the stunning results in Champions League history by overturning a two-goal deficit at hugely-fancied Paris Saint-Germain in the last round, the English side will hope to achieve another gig result.
Ole Gunnar Solskjær’s resurgent United lost 2-0 to Paris Saint-German at Old Trafford but breaks the Champions League record of being the first team win after losing by two goals margin home.
Barcelona, with Lionel Messi, are in sensational form as Ernesto Valverde’s Blaugrana all but wrapped up the Spanish title race with a 2-0 win over Atletico Madrid on Saturday.
Messi has scored 13 goals and set up another four in his last 10 games, and now Solskjaer’s job will be to prevent Argentine magician from lighting up Old Trafford.
Man United Team News
Marcus Rashford and Nemanja Matic are available to feature in the match after Rashford missed last week’s trip to Wolves with an ankle injury.
Eric Bailly, Alexis Sanchez and Antonio Valencia would be absent. Ander Herrera is also likely to miss out through injury.
Barcelona Teams News
Ousmane Dembele is in training again after suffering an injury at home to Lyon in the last 16, but the French forward looks unlikely to return at Old Trafford.
Man United vs Barcelona Possible Line-ups
Man Utd XI: De Gea, Young, Smalling, Lindelof, Shaw, Matic, McTominay, Pogba, Lingard, Rashford, Martial
Barcelona XI: Ter Stegen, Sergi Roberto, Pique, Lenglet, Alba, Busquets, Rakitic, Arthur, Vidal, Messi, Suarez