The two sides have only met once this season, in the English Premier League, with City getting the better of the north Londoners 1-0.
Mauricio Pochettino and his men have all to play for, knowing that a loss at home to the Citizens could be a disaster for the team’s progression to the next round of the competition.
On their part, Manchester City secured a place in the final of the FA Cup by defeating Brighton 1-0.
The Citizens have already won the EFL Cup and are still in pole position to win the English Premier League.
Meanwhile, it could be said that winning the UEFA Champions League is their utmost target.
But Pep Guardiola has warned his team to shift focus from the possibility of winning quadruple, else it will affect the team.
Tottenham Team News
Tottenham have no player suspended for the encounter with yellow cards wiped at this stage of the competition. But there are still injury worries for the team as Eric Dier and Erik Lamela are still out with injuries. Meanwhile, Serge Aurier is unlikely to recover from his hamstring injury.
Manchester City News
Like Tottenham, Manchester City have no player suspended for this round, but the Citizens have the fitness of talisman Sergio Aguero to worry about. However, with Benjamin Mendy returning, there is a boost in the defence of the EPL champions.
Tottenham vs Manchester City Possible Line-ups
Man City XI: Ederson, Walker, Laporte, Otamendi, Mendy, Gundogan, Fernandinho, De Bruyne, Bernardo Silva, Sterling, Aguero
Tottenham XI: Lloris, Trippier, Alderweireld, Vertonghen, Davies, Sissoko, Alli, Eriksen, Son, Rose, Kane