Man City travels to Spurs’ 62,062 capacity new home in London for the Tuesday’s Champions League quarter-final first leg.
The Belgium international is confident that the new atmosphere will not have a negative effect on their quadruple pursuit.
“I don’t care about the stadium, I care about the team we play.
“Everybody talks about the stadium like it’s something special. Everybody has a stadium. Everybody has supporters. They’ll be up for it.
“I don’t think there will be any different. They’ll probably be a little bit more excited, but in the end, it’s a stadium with supporters.
“If they go to Wembley with 80,000 or there with 62,000, it’s going to be the same. It’ll be a tough game, but I think we’ll be all right.”
City secured their place in the FA Cup final with a 1-0 win against Brighton on Saturday.
The Premier League title is still in their hands – and they have already picked up the first piece of silverware this season in the EFL Cup.
Guardiola describes a clean sweep as virtually impossible – and De Bruyne insists the quadruple is not on the players’ minds.
“There’s no point thinking about it,” he said. “Do you know how heavy the schedule is? I think people underestimate how the fixtures come that quickly. You can’t think about it.
“We don’t even have time to have a rest ourselves so how can we think about what’s going to happen in four weeks?
“We’re just going to play Tuesday and then hopefully play a good game.”
Guardiola believes Spurs have the advantage on Tuesday after having a free weekend to prepare for the visit of City.