Ajax, who last won the Champions League trophy in 1995, enter the last-16 clash for the first time since the 2005/06 season.
But Madrid should be wary of this team known as de Godenzonen as they are unbeaten in the competition this season.
“Top teams can play very offensively, but also shut up tight and then break at pace. Real Madrid have a very experienced team, with guys like (Sergio) Ramos, (Toni) Kroos, (Luka) Modric and (Karim) Benzema, but also a good mix,” Erik Ten Hag, coach of the side, said ahead of the clash.
“It is going to be a great challenge for us to achieve something positive. We know we can be strong on this stage, and certainly in Amsterdam.”
As for the Los Blancos, they are looking to win their fourth straight Champions League trophy this season.
Speaking ahead of the game, head coach of the 13-time European champions, Santiago Solari, said his side were fully focused on the match.
Solari said: “We have great memories of this stadium. Let’s hope that continues tomorrow. They’re a side who link up well, build the play well and have good players. You have to respect every opponent. I hope we produce a performance as serious as we did three days ago.”
Concise News understands that Frenkie De Jong is set to feature in the game after he was forced off the pitch 10 minutes from time in his team’s defeat to Heracles Almelo on Saturday.
It was also learned that Ajax are worried over the fitness of Nicolas Tagliafico. He completed Saturday’s match but has been battling with a knee problem.
On the other side, Solari could retain the team that beat rivals Atletico Madrid 3-1 on Saturday.
Jesus Vallejo and Luca Zidane are both ruled out (hamstring). While midfielder Isco was not included in Real’s 23-man squad due to a back and neck injury.
Kick-off time is 9pm in Nigeria.