Not many fans and pundits tipped United to overcome the Paris club when the draw for this round was conducted in December, 2018, because the English side were in disarray at the time.
But now, it is quite difficult to predict against the Red Devils.
Under the Norwegian, United have won 10 of 11 games to move into the Premier League top four.
Midfielder Paul Pogba is playing with a remarkable swagger. The Frenchman and Anthony Martial gave Man United a 2-0 half-time lead at Fulham last weekend, before a Pogba penalty sealed a 3-0 win.
Pogba has netted eight goals and five assists in 10 matches, while Marcus Rashford has been in great form, too.
As for PSG, this is not the best time to visit Old Trafford. They struggled to beat Lyon 2-1 in Ligue 1 after recording a 3-0 extra time win against third tier Villefranche in the Coupe de France.
The French giants needed an Edinson Cavani penalty to overcome Bordeaux on Saturday.
But something unwanted happened.
Cavani suffered an injury while taking the penalty and likely to miss out on the clash at Old Trafford.
Manager Thomas Tuchel has other worries.
Brazilian superstar Neymar had been ruled out of both legs with a foot injury, and Marco Verratti is also likely to miss the game.
Concise News understands that right-back Thomas Meunier will miss out after suffering a concussion during Saturday’s match.
Man United: De Gea; Young, Lindelöf, Jones, Shaw; Herrera, Matić, Pogba; Lingard, Rashford, Martial
Out: Darmian (knock), Valencia (muscular)
Doubtful: Rojo (knee)
Misses next game if booked: Matić, Valencia
PSG: Buffon; Kehrer, Thiago Silva, Kimpembe, Bernat; Marquinhos, Verratti; Dani Alves, Draxler, Di María; Mbappé
Out: Neymar (foot), Cavani (hip), Meunier (concussion)
Misses next game if booked: Kehrer, Neymar, Verratti
Man United: WWDWWWWWWW (all competitions, most recent first)
Stats you should know
1. Manchester United have won 10 of their last 11 matches in all competitions.
2. Manchester United have scored 2 or more goals in their last 7 home matches (all competitions).
3. Manchester United’s Paul Pogba has scored 8 goals in his last 10 matches (all competitions).
4. PSG have lost 3 of their last 5 away matches (Uefa Champions League).
5. PSG’s away record against English clubs is W1 D4 L5 (Uefa Champions League).