Striker Alexis Sanchez is facing a long lay-off with a hamstring injury, Manchester United manager Jose Mourinho said on Friday.
The Chile international sustained the problem in training on Thursday.
This is another setback for Sanchez, who has struggled to make an impact at United after his move from Arsenal in January,
Speaking ahead of the trip to Southampton, Mourinho said: “It is an aggressive muscular injury.
“He has not had a scan yet but the player is experienced. He knows what injury is.
“From my experience, the painful scream and way it happened, it will be a long time.
“I don’t want to risk by saying for how long he will be out but from the top of my experience I would say he is not playing this year.”