Tennis greats Federer and Serena Williams (iamge courtesy Tennis World)

Tennis greats Serena Williams and Roger Federer will go head-to-head in 2019 when the USA take on Switzerland in the mixed doubles at the Hopman Cup.

The 37-year-old Williams has not played since her meltdown at the US Open final in September. The 23-time Grand Slam winner lost to Naomi Osaka.

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Williams partners Frances Tiafoe, while 20-time Grand Slam winner Federer and Belinda Bencic will seek to defend their title.

“The Aussie fans are always so warm and supportive and the Hopman Cup has always given me a great start to the season, especially ahead of the Australian Open,” said Williams, who pulled out of this month’s China Open.

The Hopman Cup runs from 29 December until 5 January, with the 2019 Australian Open taking place from 14-27 January.

The mixed team event features eight nations split into two groups, with teams facing each other in sessions that consist of a men’s and women’s singles match and a mixed doubles match.

Each team plays the other three in their group, and the top teams in each group then meet in the final.