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Caroline Wozniacki has crashed out of the 2018 Wimbledon Open after losing 6-4, 1-6, 7-5 to Ekaterina Makarova in the second round on Wednesday.

Wozniacki has now failed to get past the last 16 in 12 visits to the All England Club.

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It was a bitter defeat for the 27-year-old Dane, who was expected to challenge for the Wimbledon title after winning the Australian Open in January.